Introduction:

Chryseobacterium indologenes is an uncommon, multidrugresistant, non-fermenting Gram-negative bacillus increasingly recognized as an opportunistic nosocomial pathogen. Although typically associated with device-related infections and hospital water sources, central nervous system involvement remains sporadic. Its intrinsic resistance to many broad-spectrum antibiotics makes timely identification and tailored therapy of paramount importance.

Case presentation:

A 55-year-old man with metabolic comorbidities developed fever, neck stiffness and generalized body ache several weeks after undergoing retrosigmoid suboccipital craniotomy for tumor removal. CSF culture confirmed C. indologenes, a multidrug-resistant organism requiring targeted antimicrobial therapy. The patient improved with directed treatment and supportive care.

Conclusion:

This case illustrates a rare but clinically significant instance of C. indologenes meningitis, emphasizing the importance of considering atypical pathogens in patients with recent neurosurgical procedures or healthcare exposure.