Background: Polyphenolic compounds, including grape seed-derived oligomeric procyanidins, have demonstrated antioxidant and vascular benefits, yet human data on their neurocognitive and mood effects remain limited. Enovita™ is a standardized oligomeric procyanidin-rich extract derived from Vitis vinifera seeds, previously shown to support microvascular health.

Objective: To evaluate the acute and chronic effects of grape seed extract supplementation on cognitive performance and mood states in healthy adults.

Methods: In this randomized, double-blind, placebo-controlled pilot trial, 32 healthy participants ages 25–55 years were randomized to receive twice daily either 150 mg of standardized grape seed extract (Enovita™, 300 mg/day) or placebo for 4 weeks. Mood was assessed using the abbreviated profile of mood states, and cognitive performance was measured with the 4-part continuous performance test at baseline, 60 mins, 180 mins postdose, and after 4 weeks. Trial Registration: NCT06309914.

Results: Grape seed extract was well tolerated with high compliance and no serious adverse events. After 4 weeks, all mood subscales showed directional improvement in the grape seed extract group compared to placebo, with the greatest deltas observed for anger (−1.19 vs. +0.62) and depression (−0.62 vs. +1.31). A significant group-by-time interaction was found in working memory performance at 4 weeks (p=0.050), with reduced errors in the grape seed extract group (−1.19) compared to increased errors in the placebo (+1.06).

Conclusion: Daily supplementation with a sustainable standardized Grape seed extract may support mood balance and working memory in healthy adults. These preliminary results warrant confirmation in larger, longerterm trials including mechanistic assessments.