Dr. Mohammad Omar Faruque Miah^*,1, Dr. Fahima Akter Dowel², Dr. Muhammad Shahidullah³, Dr. Choman Abdullah Mohana⁴

¹Associate Professor, Department of Nephrology, Mymensingh Medical College & Hospital, Mymensingh, Bangladesh

²Senior Medical Officer, Institute of Nuclear Medicine and Allied Sciences (INMAS), Mymensingh, BAEC, Bangladesh

³Associate Professor, Department of Medicine, Mymensingh Medical College & Hospital, Mymensingh, Bangladesh

⁴Assistant Professor, Department of Endocrinology, Mymensingh Medical College & Hospital, Mymensingh, Bangladesh

*Corresponding Author: Dr. Mohammad Omar Faruque Miah, Associate Professor, Department of Nephrology, Mymensingh Medical College & Hospital, Mymensingh, Bangladesh.

Received: 06 March 2026; Accepted: 16 March 2026; Published: 30 March 2026

Article Information

Citation: Dr. Mohammad Omar Faruque Miah, Dr. Fahima Akter Dowel, Dr. Muhammad Shahidullah, Dr. Choman Abdullah Mohana. Presenting Features and Short-Term Outcomes of Paraquat Poisoning in a Tertiary Care Hospital of Bangladesh. Fortune Journal of Health Sciences. 9 (2026): 156-161.

DOI: 10.26502/fjhs.405

Abstract

Keywords

Paraquat poisoning; agricultural pesticide; clinical features; short-term outcomes; acute renal failure; toxicity

Article Details

Introduction

Paraquat is a highly effective, non-selective, and fast-acting herbicide that remains widely used in agriculture worldwide. Owing to its pronounced acute toxicity, even minimal ingestion or dermal exposure can result in severe systemic injury, necessitating specialized handling, protective equipment and training. ^[1] Despite being banned or strictly regulated in more than 67 countries because of its high toxicity and the absence of a specific antidote, paraquat continues to be used extensively, particularly in South-east Asia and Pacific regions, largely due to its low cost and agricultural efficiency. ^[2]

Paraquat toxicity predominantly involves the lungs, kidneys, liver, and gastrointestinal tract. Following ingestion, the compound is actively concentrated in pulmonary tissue via the polyamine transport system, where it generates reactive oxygen species (ROS) through redox cycling. This process leads to lipid peroxidation, alveolar epithelial damage and progressive pulmonary fibrosis. Concurrent oxidative stress and systemic inflammation contribute to subsequent renal and hepatic dysfunction. ^[3]

The World Health Organization (WHO) lists paraquat as a Class II moderately hazardous pesticide and Pesticide Action Network International as a highly hazardous pesticide. ^[4] Ingestion of very minute amounts ultimately leads to development of acute multi-organ failure, even death. ^[5] Mortality rate is 60–80% across the planet; about 20 deaths per million individuals worldwide take place as a result of acute paraquat poisoning. ^[4-5]

The diagnosis is largely clinical, based on the history of exposure and presenting features. Laboratory confirmation includes urine dithionite test or plasma paraquat level measurement, although availability of these tests is limited in resource-constrained settings. Coming to the treatment, there are no standard guidelines for the management of this condition as of now. Interventions include preventing paraquat absorption with activated charcoal or gastric lavage, increasing paraquat elimination by hemodialysis and administering glucocorticoids, immunosuppressants and antioxidants. However, this approach does not provide remarkable benefits in preventing the toxicities of paraquat. ^[3]

Despite all, paraquat is readily available in agrochemical shops under various trade names and often used without proper personal protective equipment (PPE) in Bangladesh. It is a major cause of poisoning-related hospital admissions, particularly in rural regions, where intentional self-poisoning is a common mode of exposure. A retrospective analysis conducted at the Dhaka Medical College Hospital (DMCH) reported that paraquat was responsible for up to 13.6% of all pesticide poisoning cases, with a case fatality rate exceeding 70%. ^[6] Another study in Chattogram Medical College Hospital discovered similar findings, where most victims were young adults (aged 15–30) and had ingested the poison with suicidal intent. ^[7]

Studies confirm that banning or severely restricting paraquat directly leads to a significant decline in suicide rates and fatal, often impulsive, poisoning cases. ^[1] However, the continued, widespread use of paraquat highlights significant gaps in global pesticide regulation, mental health support and agricultural safety practices. The persistent use can be linked to several factors such as weak enforcements of regulations, lack of competitive alternatives, ineffective restrictions and lack in training. ^[1]

There is dearth of published literature on paraquat poisoning in Bangladesh as it is grossly under-reported, as well as the true burden is not well-documented. Therefore, the aim of this study was to evaluate the clinical presentations and short-term outcomes of the patients.

Methods

Study design

This was a prospective observational study conducted over a six-month period from January 2023 to July 2023.

Study setting

The study was carried out in the Departments of Nephrology and Medicine at Mymensingh Medical College Hospital (MMCH), a tertiary care referral center in Bangladesh.

Study population and sample size

A total of 54 patients with a confirmed history of paraquat ingestion were enrolled in the study. The sample size was determined based on real-world case availability during the study period.

Sampling technique

Purposive consecutive sampling was employed, whereby all eligible patients presenting during the study period were included until the desired sample size was reached.

Eligibility criteria

Patients with a confirmed history of paraquat ingestion within the preceding seven days were included and patients who declined to provide informed consent were excluded from the study.

Data collection procedure

Demographic information and clinical data were collected using a standardized data collection sheet at the time of admission. Clinical evaluation focused on gastrointestinal, renal, hepatic, and respiratory manifestations.

Blood (3 mL) and urine (10 mL) samples were obtained for laboratory investigations. The following tests were performed:

• • Complete blood count (CBC)
• • Random blood sugar (RBS)
• • Serum creatinine
• • Serum alanine aminotransferase (ALT)
• • Serum electrolytes (sodium, potassium, chloride)
• • Urine routine microscopic examination (RME)

Additional investigations included chest X-ray (CXR) and electrocardiogram (ECG), as clinically indicated.

Follow-up and outcome assessment

Patients were followed for a period of up to five weeks following ingestion. Outcomes were assessed in terms of clinical recovery or adverse outcome during the follow-up period. The need for renal replacement therapy, including hemodialysis, was recorded.

Ethics

The study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. Ethical approval was obtained from the Institutional Review Board (IRB) of MMCH prior to commencement of the study. Written informed consent was obtained from all participants or their legally authorized guardians before enrollment. Confidentiality of patient information was strictly maintained throughout the study. Personal identifiers were removed from the data collection forms and all clinical data were used solely for research purposes. Participation in the study was voluntary, and patients were informed of their right to withdraw from the study at any stage without any impact on their standard medical care.

Results

Table 1: Baseline characteristics of the participants [n=54]

Mean age of the respondents was 21.98 ± 8.85 years and majority of them were males [33, 61.1%]. A significant proportion of patients (57.4%) hailed from Mymensingh. Lastly, maximum patients [42, 77.8%] were brought to the hospital within 24 hours of accidental/intentional ingestion.  (Table 1).

Figure 1: Bar chart demonstrating clinical features of the participants

Concerning renal outcomes, majority of the patients [72.2%] developed renal failure after ingestion of paraquat. (Figure 2).

Figure 2: Pie chart illustrating the distribution of renal failure among the study subjects

Regarding requirement of hemodialysis of the patients, it is clearly evident that approximately one-third patients [35.2%] received hemodialysis treatment. (Figure 3).

Figure 3: Pie chart showing the distribution of participants according to requirement of hemodialysis.

Table 2: Laboratory findings of the study subjects [n=54]

It is visible that, mean serum creatinine level was highly elevated in the patients [4.31 mg/dL]. Also, mean S. alanine aminotransferase was mildly raised [70.4 IU/L] Other tests such as hemoglobin, blood sugar and serum electrolytes were mostly within the normal range. (Table 2). Lastly, it was found that, the majority of the patients [57.4%] could not survive despite hospital admission. (Figure 4).

Figure 4: Column bar demonstrating the final outcomes of the respondents.

Discussion

This prospective observational study describes the clinical characteristics, renal involvement, and short-term outcomes of paraquat poisoning in a tertiary care hospital in Bangladesh.

The mean age of patients in this study was 21.98 ± 8.85 years, with the majority below 30 years of age. This is comparable to findings reported from Sri Lanka, India, and China, where paraquat poisoning predominantly affects young adults aged 15–30 years. ^[8] Gawarammana et al. and Wilks et al. reported similar age distributions, attributing this pattern to impulsive ingestion and easy access to agricultural pesticides among younger populations. ^[9-10]

Male predominance (61.1%) observed in this cohort is consistent with studies from South Asia and Southeast Asia, where males account for 55–70% of paraquat poisoning cases. This has been linked to greater occupational exposure and higher prevalence of pesticide use among males in agricultural communities. ^[11]

In the present study, 77.8% of patients presented within 24 hours of ingestion. This rate of early presentation is higher than that reported in several regional studies, where delayed presentation beyond 24 hours ranged from 35% to 50%. Despite earlier hospital arrival in this cohort, outcomes remained poor, suggesting that early presentation alone may not significantly alter prognosis in the absence of effective antidotal or extracorporeal detoxification therapies. ^[8]

Gastrointestinal manifestations were the most frequent presenting symptoms, with nausea (96.3%), altered conciousness (88.9%), vomiting (79.6%), and oral ulceration (75.9%). Relevant literature reported vomiting and loss of consciousness to be the outstanding clinical features. ^[11] In another paper by Oghabian et al. it was found that, oral ulceration, respiratory distress and excessive salivation were the most commonly encountered features among the paraquat poisoning cases. ^[12]

Renal failure occurred in 72.2% of patients, confirming the kidney as a major target organ in paraquat toxicity. This incidence is consistent with existing literature, where acute kidney injury rates ranged from 60% to 80%. ^[13] The mean serum creatinine level of 4.31 mg/dL in this study is comparable to values reported in regional and worldwide context, indicating substantial nephrotoxicity. ^[14]

Hemodialysis was required in 35.2% of patients. Similar proportions have been reported in regional studies; however, multiple authors have demonstrated that conventional hemodialysis does not significantly improve survival unless combined with early hemoperfusion. ^[15]

Aside from elevated serum creatinine and mild transaminase elevation, most laboratory parameters were within normal limits. Comparable biochemical patterns have been reported in prior studies, where renal and hepatic markers were the most consistently affected laboratory variables. Electrolyte disturbances were not prominent in this cohort, consistent with findings from several hospital-based series where abnormalities were largely secondary to vomiting or renal dysfunction rather than direct toxicity. ^{[8, 11]}

Paraquat damages the heart, kidneys, liver, adrenal glands, central nervous system, muscles and spleen causing multiple organ failure. Several literature associated paraquat poisoning with acute lung injury, pulmonary hypertension, leukocytosis, metabolic acidosis, enlarged heart, acute kidney injury, generalized edema and increased level of amylase, glucose and creatinine. ^[16]

The mortality rate in this study was 57.4%, which falls within the range reported internationally (40–70%). Similar fatality rates have been reported in hospital-based studies from Bangladesh, India, and China. ^[17] An important finding reported was that, mortality correlates with blood plasma levels, with levels >0.2mg/mL at 24 hours often being fatal. Studies from countries that have implemented national bans on paraquat, such as Sri Lanka and South Korea, have demonstrated a marked reduction in poisoning-related deaths, highlighting the importance of regulatory interventions rather than reliance on clinical management alone. ^[18-21]

This study has several limitations. First, it was a single-center study with a relatively small sample size, which may limit the generalizability of the findings. Second, detailed information regarding patients’ mental health status, psychosocial stressors, and intent of ingestion was not systematically assessed, precluding analysis of underlying behavioral and psychiatric risk factors. Third, quantitative confirmation of paraquat exposure using plasma paraquat levels or urine dithionite testing was not available, and diagnosis relied primarily on clinical history. Finally, follow-up was restricted to five weeks, and long-term complications, particularly chronic pulmonary and renal sequelae, could not be assessed.

Conclusion

The present study demonstrates that paraquat poisoning predominantly affects young adults and is associated with severe multisystem involvement, particularly acute renal failure. Despite early hospital presentation in most cases, short-term outcomes remain poor, with high mortality rates. These findings reinforce the need for stricter regulatory control of paraquat, improved access to advanced supportive therapies, and the development of standardized national management guidelines.

Conflict of interest

The authors disclose no conflict of interest.

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