Efficacy of Tramadol Hydrochloride with added Adrenaline and Tramadol Hydrochloride without Adrenaline as local anesthetic

Author(s): Gourab Paul, Hiralal Ash, Anu Singh, Abhishek Kumar, Swastika Sen

Introduction: Local anesthetics are agents that reversibly interfere with neural conduction and are widely used to provide pain control in dental treatments. Tramadol has been reported to have anesthetic activity on peripheral nerves. When administered locally, it has both analgesic and anesthetic properties. The purpose of our study was to compare the local anesthetic effect of tramadol hydrochloride solution with adrenaline versus tramadol hydrochloride solution without adrenaline for nonsurgical extraction of maxillary tooth.

Materials and Methods: This double blinded randomized study was conducted in the department of oral & maxillofacial surgery of Buddha Institute of Dental Sciences and Hospital, Patna. A total 100 patients were selected from study population and randomly divided by lottery method in two groups who required extraction of maxillary tooth by intra alveolar method. GROUP A (50 patients)- Each patient received an initial dose of 1 syringe (1.8 mL) of drug A (mixture of tramadol HCl 50 mg and adrenalin 0.0225 mg diluted to 1.8 mL by distilled water). GROUP B (50 patients)- Each patient received an initial dose of 1 syringe (1.8 mL) of drug B (tramadol HCl 50 mg diluted to 1.8 mL by distilled water).

Results: We observed significant difference in Pain, Number of used syringe and per-operative bleeding whereas non-significant difference in Onset between group A and group B (p=0.092).

Conclusion: Supraperiosteal infiltration of tramadol HCl in combination with adrenaline was shown to be a very effective local anesthetic for the extraction of upper teeth and can be used as an alternative local anesthesia.